The Vinjamuru Domain is an important crustal segment in the Nellore schist belt (NSB) and the tectono-metamorphic evolution of the belt provides insights into Proterozoic orogenesis in southeastern India, and is also relevant to an Indo-Antarctic correlation in the Late Paleoproterozoic and Middle Mesoproterozoic. Garnet-staurolite-kyanite bearing metapelites in this domain exhibit three metamorphic stages, e.g. M-1S, M-2S and M-3S in the Saidapuram-Sangam area (sector-S) and M-1N, M-2N and M-3N in the Vinjamuru-Malakonda area (sector-N). In both sectors, the metapelites exhibit shallow foliation (S-2) axial planar to recumbent folds (F-2) of an earlier schistosity (S-1), and overprinted by gently-plunging upright F-3 folds, with axial planar fabric (S-3) trending north in sector-S, and NNE in sector-N. Syn-D-3S garnet + staurolite + kyanite + muscovite + biotite + quartz + ilmenite plagioclase and garnet (late-D-2N to early-D-3N) + kyanite + muscovite + biotite + quartz + ilmenite +/- plagioclase +/- staurolite assemblages characterize the peak metamorphic episodes in the sector-S (M-3S, P = 8.8-9.2 kbar, T = 630-650 degrees C) and sector-N (M-3N, P = 6.5-7.5 kbar, T = 620-640 degrees C) respectively. The peak P-T conditions in the metapelites (M-3S/M-3N) are broadly contemporaneous with the steep-dipping S-3S in sector-S and shallow-dipping S-2N in sector-N. Total-Pb monazite dating in the chemically distinct monazite domains yields age populations at 1.65-1.55 Ga, 1.50-1.40 Ga, 1.38-1.25 Ga and 0.84-0.76 Ga. The oldest age population (1.65-1.55 Ga) possibly corresponds to large-scale reworking of the pre-existing crust in the Vinjamuru domain. Subsequently, the domain experienced prograde metamorphism (M-1S/M-1N-M-2S/M-2N) between 1.50 and 1.40 Ga, which may be attributed to a mid-crustal shortening within the NSB. The 1.38-1.25 Ga ages correspond to upper amphibolite facies metamorphism (M-3S/M-3N) and coincides with widespread felsic plutonism in the NSB. The Neoproterozoic ages (0.84-0.76 Ga) arguably represent an alteration event that affected the NSB during Rodinia supercontinent breakup. The Mesoproterozoic metamorphism and the long-lived orogenic events (1.65-0.76 Ga) in the Vinjamuru domain are similar to those recorded in the basement rocks of East Antarctica, suggesting a possible tectonic linkage along accretionary margins.