Tag/Conjugate
Unconjugated
Alternative Names
Keratin 19; KRT19
Buffer
Lyophilizedfrom 30mM Tris/HCl, pH 8 containing 9.5M urea, 2mM DTT, 2mM EDTA and 10Mmmethylammonium chloride
Storage
2-8°C short term, -20°C long term
Introduction
Keratin19 is a member of the keratin family. The keratins are intermediate filamentproteins responsible for the structural integrity of epithelial cells and aresubdivided into cytokeratins and hair keratins. Keratin 19 is a type Ikeratin. The type I cytokeratins consist of acidic proteins which arearranged in pairs of heterotypic keratin chains. Unlike its related familymembers, this smallest known acidic cytokeratin is not paired with a basiccytokeratin in epithelial cells. It is specifically found in the periderm,the transiently superficial layer that envelops the developing epidermis. Thetype I cytokeratins are clustered in a region of chromosome 17q12-q21.
Keywords
KRT19; keratin 19; K19; CK19; K1CS; keratin, type I cytoskeletal 19
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Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
Prasad, ML; Pellegata, NS; et al. Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors. MODERN PATHOLOGY 18:48-57(2005).
COA
Certificate of Analysis
