Homoarginine ELISA Kit

Sample

Plasma, Serum, Cell Culture Samples

Species Reactivity

Human

Intended Use

Enzyme Immunoassay for the Quantitative Determination of Homoarginine in Plasma, Serum and Cell Culture Samples

Storage

On arrival, store the kit at 2-8 °C. Once opened the kit is stable until its expiry date. For stability of prepared reagents refer to Preparation of Reagents.
Do not use components beyond the expiration date shown on the labels. Do not mix various lots of any kit component within an individual assay.

Detection Range

2.0 ± 0.7 μmol/L

Sensitivity

0.05 μmol / l

General Description

Homoarginine is a non-essential cationic amino acid, which is formed from lysine. In vitro and in vivo, homoarginine shows characteristics similar to arginine. Epidemiological investigations in two large independent cohorts, namely the German diabetes dialysis (4D) - study and the Ludwigshafen Risk and Cardiovascular Health (LURIC) - study have identified homoarginine as useful predictor of cardiovascular events and mortality.
Beyond that homoarginine concentrations are directly correlated with kidney function and are significantly associated with the progression of chronic kidney disease (CKD). Low homoarginine concentrations might be an early indicator of kidney failure and a potential target for the prevention of disease progression which needs further investigations. Furthermore homoarginine could be a useful marker for the monitoring of hemodialysis patients.

Standard Curve