Anti-HOXD11 monoclonal antibody (DMABT-H13934)
Mouse anti-Human HOXD11 monoclonal antibody for WB, IHC, IF, sELISA, ELISA
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HOXD11 (NP_067015,2a.a. ~ 76 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
HOXD11; homeobox D11; homeo box D11 , HOX4, HOX4F; homeobox protein Hox-D11; homeo box 4F; homeo box D11
HOXD11 (Homeobox D11) is a Protein Coding gene. Diseases associated with HOXD11 include syndactyly, type v and brachydactyly-syndactyly syndrome. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD10. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis.
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Homeobox protein Hox-D11 is a protein that in humans is encoded by the HOXD11 gene. 0The function about HOXD11 antigen include sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity.
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Cantile, M; Schiavo, G; et al. Expression of lumbosacral HOX genes, crucial in kidney organogenesis, is systematically deregulated in clear cell kidney cancers. ANTI-CANCER DRUGS 22:392-401(2011).
Villavicencio-Lorini, P; Kuss, P; et al. Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation. JOURNAL OF CLINICAL INVESTIGATION 120:1994-2004(2010).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.