Anti-HOXD11 monoclonal antibody (DMABT-H13934)

Mouse anti-Human HOXD11 monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
7D9
Species Reactivity
Human
Immunogen
HOXD11 (NP_067015,2a.a. ~ 76 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
HOXD11; homeobox D11; homeo box D11 , HOX4, HOX4F; homeobox protein Hox-D11; homeo box 4F; homeo box D11
Entrez Gene ID
UniProt ID

Product Background


Gene summary
HOXD11 (Homeobox D11) is a Protein Coding gene. Diseases associated with HOXD11 include syndactyly, type v and brachydactyly-syndactyly syndrome. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD10. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis.
Antigen Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Homeobox protein Hox-D11 is a protein that in humans is encoded by the HOXD11 gene. 0The function about HOXD11 antigen include sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity.

Citations


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References


KANZLER, B; VIALLET, JP; et al. DIFFERENTIAL EXPRESSION OF 2 DIFFERENT HOMEOBOX GENE FAMILIES DURING MOUSE TEGUMENT MORPHOGENESIS. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 38:633-640(1994).
Lopez, R; Garrido, E; et al. A subgroup of HOX Abd-B gene is differentially expressed in cervical cancer. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 16:1289-1296(2006).

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