Specificity
Expressed in platelets, smooth muscle and prostate stromal cells (at protein level).
Tag/Conjugate
Unconjugated
SequenceSimilarities
Belongs to the paxillin family.Contains 4 LIM zinc-binding domains.
Alternative Names
The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Function
I-SMAD binding; Roundabout binding; androgen receptor binding; androgen receptor binding; protein binding; transcription coactivator activity; transcription coactivator activity; zinc ion binding;
Synonyms
TGFB1I1; transforming growth factor beta 1 induced transcript 1; HIC5; ARA55; HIC-5; TSC-5; transforming growth factor beta-1-induced transcript 1 protein; androgen receptor coactivator ARA55; hydrogen peroxide-inducible clone 5 protein; androgen receptor coactivator 55 kDa protein; androgen receptor-associated protein of 55 kDa;
Citations
Publication ()
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COA
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