This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
Function
DNA binding; protein dimerization activity; sequence-specific DNA binding transcription factor activity; transcription cofactor activity; transcription factor binding;
Synonyms
HES6; hes family bHLH transcription factor 6; HES-6; bHLHb41; bHLHc23; C-HAIRY1; transcription cofactor HES-6; hairy and enhancer of split 6; class B basic helix-loop-helix protein 41;
Citations
Publication ()
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