HCG-beta [HRP]

Name: HCG-beta [HRP]
SKU: DAGA-776
Rating: 5 (1 reviews)

HCG-beta-HRP enzyme conjugate, native protein from human

COA

SDS

Datasheet

Summary

Nature

Native

Tag/Conjugate

HRP

Alternative Names

Human chorionic gonadotropin; hCG; pregnancy tests; β-hCG; β-subunit of hCG

Format

Liquid

Concentration

Batch dependent - please inquire should you have specific requirements

Buffer

0.05 M Tris with protein additives, pH 7.6

Preservative

None

Storage

2-8°C

Antigen Description

Human chorionic gonadotropin (hCG) is a hormone produced by the placenta after implantation.Regarding endogenous forms of hCG, there are various ways to categorize and measure them, including total hCG, C-terminal peptide total hCG, intact hCG, free β-subunit hCG, β-core fragment hCG, hyperglycosylated hCG, nicked hCG, alpha hCG, and pituitary hCG.Blood or urine tests measure hCG. These can be pregnancy tests. hCG-positive indicates an implanted blastocyst and mammalian embryogenesis. These can be done to diagnose and monitor germ cell tumors and gestational trophoblastic diseases.

Keywords

Human chorionic gonadotropin;hCG;pregnancy tests;β-hCG;β-subunit of hCG

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Presence and release of SR-17 (chromogranin B586-602) in the porcine splenic nerve and its enzymatic degradation by CD26/dipeptidyl peptidase IV

REGULATORY PEPTIDES

Authors: Depreitere, J; Durinx, C; Wang, ZS; Coen, E; Lambeir, AM; Scharpe, S; De Potter, W; Nouwen, EJ

Abstract

Using the pig splenic nerve as a model, we investigated the proteolytic processing of porcine chromogranin B (CgB) during its axonal transport. An ELISA was developed for SR-17 (CgB(586-602)), a novel CgB-derived peptide, originally found in the adrenal medulla. The results demonstrate that CgB is processed in an early stage during its axonal transport. Immunohistochemical data, based on a rabbit anti-SR-17 antiserum, show that the spleen CgB/SR-17 is exclusively present in the nerve endings. No SR-17 immunoreactivity (IR) was found in splenocytes. We also provide evidence that SR-17 is co-released with noradrenaline (NA) upon electrical stimulation of the splenic nerve. Its release is frequency-dependent and strongly enhanced in the presence of the alpha-blocking agent phentolamine. In addition, we show that the new CgB-peptide can serve as a substrate for the lymphocyte surface glycoprotein CD26, also known as dipeptidyl peptidase IV (DPP IV), generating a new peptide ER-15 (CgB(588-602)). (C) 2002 Elsevier Science B.V. All rights reserved.

JASPAR: an open-access database for eukaryotic transcription factor binding profiles

NUCLEIC ACIDS RESEARCH

Authors: Sandelin, A; Alkema, W; Engstrom, P; Wasserman, WW; Lenhard, B

Abstract

The analysis of regulatory regions in genome sequences is strongly based on the detection of potential transcription factor binding sites. The preferred models for representation of transcription factor binding specificity have been termed position-specific scoring matrices. JASPAR is an open-access database of annotated, high-quality, matrix-based transcription factor binding site profiles for multicellular eukaryotes. The profiles were derived exclusively from sets of nucleotide sequences experimentally demonstrated to bind transcription factors. The database is complemented by a web interface for browsing, searching and subset selection, an online sequence analysis utility and a suite of programming tools for genomewide and comparative genomic analysis of regulatory regions. JASPAR is available at http://jaspar. cgb.ki.se.