Tag/Conjugate
Unconjugated
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Function
protein binding;
Synonyms
GEMIN4; gem (nuclear organelle) associated protein 4; p97; HC56; HCAP1; HHRF-1; gem-associated protein 4; gemin-4; component of gems 4; HCC-associated protein 1;
Citations
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Nelson, PT; Hatzigeorgiou, AG; et al. miRNP : mRNA association in polyribosomes in a human neuronal cell line. RNA-A PUBLICATION OF THE RNA SOCIETY 10:387-394(2004).
Yang, HS; Dinney, CP; et al. Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. CANCER RESEARCH 68:2530-2537(2008).