Anti-GSDMD monoclonal antibody (DMABT-H13873)
Mouse anti-Human GSDMD monoclonal antibody for WB, IHC, IF, sELISA, ELISA
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GSDMDC1 (AAH08904,2a.a. ~ 484 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
GSDMD; gasdermin D; gasdermin domain containing2, GSDMDC1; gasdermin-D; DF5L; FLJ12150
GSDMD (Gasdermin D) is a Protein Coding gene. An important paralog of this gene is GSDMC. Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.
Component of inflammasomes responsible for the execution of pyroptosis and the release of mature IL1B. In response to canonical, as well as non-canonical(such as cytosolic LPS) inflammasome activators, undergoes cleavage by inflammatory caspases CASP1 and CASP4, respectively. The released N-terminal moiety promotes pyroptosis and release of mature IL1B.
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Saeki, N; Usui, T; et al. Distinctive Expression and Function of Four GSDM Family Genes (GSDMA-D) in Normal and Malignant Upper Gastrointestinal Epithelium. GENES CHROMOSOMES & CANCER 48:261-271(2009).
Fujii, T; Tamura, M; et al. Gasdermin D (Gsdmd) is dispensable for mouse intestinal epithelium development. GENESIS 46:418-423(2008).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.