Anti-GSDMD monoclonal antibody (DMABT-H13873)

Mouse anti-Human GSDMD monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
4G23-2C3
Species Reactivity
Human
Immunogen
GSDMDC1 (AAH08904,2a.a. ~ 484 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
GSDMD; gasdermin D; gasdermin domain containing2, GSDMDC1; gasdermin-D; DF5L; FLJ12150
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GSDMD (Gasdermin D) is a Protein Coding gene. An important paralog of this gene is GSDMC. Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.
Antigen Description
Component of inflammasomes responsible for the execution of pyroptosis and the release of mature IL1B. In response to canonical, as well as non-canonical(such as cytosolic LPS) inflammasome activators, undergoes cleavage by inflammatory caspases CASP1 and CASP4, respectively. The released N-terminal moiety promotes pyroptosis and release of mature IL1B.

Citations


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References


Saeki, N; Usui, T; et al. Distinctive Expression and Function of Four GSDM Family Genes (GSDMA-D) in Normal and Malignant Upper Gastrointestinal Epithelium. GENES CHROMOSOMES & CANCER 48:261-271(2009).
Fujii, T; Tamura, M; et al. Gasdermin D (Gsdmd) is dispensable for mouse intestinal epithelium development. GENESIS 46:418-423(2008).

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