Synthetic Human GNB3 blocking peptide for Apuri, BL, ELISA
Blocking/Immunizing peptide for anti-GNB3 antibody
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Shipped at ambient temperature, store at -20°C.
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.
GTPase activity; GTPase binding; signal transducer activity;
GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; transducin beta chain 3; G protein, beta-3 subunit; hypertension associated protein; GTP-binding regulatory protein beta-3 chain; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3;