The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jan 2014]
Function
cytokine activity; growth factor activity; protein binding;
Synonyms
GDF2; growth differentiation factor 2; BMP9; HHT5; BMP-9; growth/differentiation factor 2; GDF-2; bone morphogenetic protein 9;
Citations
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