Anti-GCM1 monoclonal antibody (DMABT-H13827)

Mouse anti-Human GCM1 monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
3F22
Species Reactivity
Human
Immunogen
GCM1 (NP_003634, 108 a.a. ~277a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
GCM1; glial cells missing homolog2(Drosophila); GCMA, glial cells missing (Drosophila) homolog a; chorion-specific transcription factor GCMa; hGCMa; GCM motif protein 1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GCM1 (Glial Cells Missing Homolog 1) is a Protein Coding gene. Diseases associated with GCM1 include pre-eclampsia. Among its related pathways are Human Early Embryo Development. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is GCM2. This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.
Antigen Description
Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Chorion-specific transcription factor GCMa is a protein that in humans is encoded by the GCM1 gene. 0The function about GCM1 antigen include DNA binding; metal ion binding; sequence-specific DNA binding transcription factor activity; transcription factor binding; zinc ion binding.

Citations


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References


Oudejans, C; Go, A; et al. Detection of chromosome 21-encoded mRNA of placental origin in maternal plasma. RECENT ADVANCES IN PRENATAL GENETIC DIAGNOSIS :37-42(2004).
Chang, CW; Cheong, ML; et al. Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion. MOLECULAR HUMAN REPRODUCTION 19:745-755(2013).

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