FAP blocking peptide (DAG-P0494)

Synthetic FAP blocking peptide for BL Datasheet

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Specificity
Fibroblast specific.
Nature
Synthetic
Tag/Conjugate
Unconjugated
Sequence Similarities
Belongs to the peptidase S9B family.
Cellular Localization
Cell membrane. Cell projection > lamellipodium membrane. Cell projection > invadopodium membrane. Found in cell surface lamellipodia, invadopodia and on shed vesicles. Colocalized with DPP4 in invadopodia and lamellipodia of migratory activated endo
Format
Liquid
Buffer
pH: 8.50Constituents: 10% DMSO, 0.1% BSANote: 50mM Tris, 5mM EDTA
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. pH: 8.50Constituents: 10% DMSO, 0.1% BSANote: 50mM Tris, 5mM EDTA
UniProt ID
Antigen Description
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Function
dipeptidyl-peptidase activity; endopeptidase activity; metalloendopeptidase activity; peptidase activity; protease binding; protein binding; protein dimerization activity; protein homodimerization activity; serine-type endopeptidase activity; serine-type
Synonyms
FAP; fibroblast activation protein, alpha; FAPA; DPPIV; seprase; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase;

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