Anti-FXYD2 monoclonal antibody (DMABT-H13812)

Mouse anti-Human FXYD2 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
2D4-C4
Species Reactivity
Human
Immunogen
FXYD2 (AAH05302.1,2a.a. ~ 64 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
FXYD2; FXYD domain containing ion transport regulator 2; ATP1G1, HOMG2, hypomagnesemia 2, renal; sodium/potassium-transporting ATPase subunit gamma; MGC12372; sodium pump gamma chain
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FXYD2 (FXYD Domain Containing Ion Transport Regulator 2) is a Protein Coding gene. Diseases associated with FXYD2 include hypomagnesemia 2, renal and sesame syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Bile secretion. GO annotations related to this gene include transporter activity and sodium channel regulator activity. This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.
Antigen Description
Hypomagnesemia 2 (HOMG2) [MIM:154020]: A disorder due to primary renal wasting of magnesium. Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is lowered renal excretion of calcium resulting in hypocalciuria. Note=The disease is caused by mutations affecting the gene represented in this entry. Sodium/potassium-transporting ATPase gamma chain is a protein that in humans is encoded by the FXYD2 gene. 0The function about FXYD2 antigen include ion channel activity; sodium:potassium-exchanging ATPase activity; transporter activity.
Pathway
Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Carbohydrate digestion and absorption, organism-specific biosystem; Carbohydrate digestion and absorption, conserved biosystem.

Citations


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References


Feschenko, MS; Donnet, C; et al. Phospholemman, a single-span membrane protein, is an accessory protein of Na,K-ATPase in cerebellum and choroid plexus. JOURNAL OF NEUROSCIENCE 23:2161-2169(2003).
Pihakaski-Maunsbach, K; Vorum, H; et al. Locations, abundances, and possible functions of FXYD ion transport regulators in rat renal medulla. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 291:F1033-F1044(2006).

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