Anti-FXYD2 monoclonal antibody (DMABT-H13812)
Mouse anti-Human FXYD2 monoclonal antibody for WB, IHC, sELISA, ELISA
Datasheet
Specifications
Host Species
Mouse
Antibody Isotype
IgG2b
Clone
2D4-C4
Species Reactivity
Human
Immunogen
FXYD2 (AAH05302.1,2a.a. ~ 64 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Target
Alternative Names
FXYD2; FXYD domain containing ion transport regulator 2; ATP1G1, HOMG2, hypomagnesemia 2, renal; sodium/potassium-transporting ATPase subunit gamma; MGC12372; sodium pump gamma chain
Entrez Gene ID
UniProt ID
Product Background
Gene summary
FXYD2 (FXYD Domain Containing Ion Transport Regulator 2) is a Protein Coding gene. Diseases associated with FXYD2 include hypomagnesemia 2, renal and sesame syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Bile secretion. GO annotations related to this gene include transporter activity and sodium channel regulator activity. This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.
Antigen Description
Hypomagnesemia 2 (HOMG2) [MIM:154020]: A disorder due to primary renal wasting of magnesium. Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is lowered renal excretion of calcium resulting in hypocalciuria. Note=The disease is caused by mutations affecting the gene represented in this entry. Sodium/potassium-transporting ATPase gamma chain is a protein that in humans is encoded by the FXYD2 gene. 0The function about FXYD2 antigen include ion channel activity; sodium:potassium-exchanging ATPase activity; transporter activity.
Pathway
Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Carbohydrate digestion and absorption, organism-specific biosystem; Carbohydrate digestion and absorption, conserved biosystem.
Citations
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References
Flamez, D; Roland, I; et al. A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gamma a as a pancreatic beta cell-specific biomarker. DIABETOLOGIA 53:1372-1383(2010).
Hutton, JC; Davidson, HW; et al. Getting beta all the time: discovery of reliable markers of beta cell mass. DIABETOLOGIA 53:1254-1257(2010).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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