Synthetic Human FOXP2 blocking peptide for Apuri, BL, ELISA
Blocking/Immunizing peptide for anti-FOXP2 (internal) antibody
Human, Mouse, Dog, Rat
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Shipped at ambient temperature, store at -20°C.
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
DNA binding; DNA binding, bending; chromatin binding; double-stranded DNA binding; metal ion binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific D
FOXP2; forkhead box P2; SPCH1, TNRC10; forkhead box protein P2; CAG repeat protein 44; CAGH44; forkhead/winged helix transcription factor; speech and language disorder 1; trinucleotide repeat containing 10; forkhead/winged-helix transcription factor; trinucleotide repeat-containing gene 10 protein; SPCH1; TNRC10; DKFZp686H1726;