General Notes
This product (Catalog No. CABT-BL1555) is a rabbit-derived IgG polyclonal antibody raised against human FOXI3, targeting the amino acid region 121–220 of the protein. This antibody exhibits cross-reactivity with FOXI3 from mouse, rat, cow, horse, and sheep. It has been affinity purified by protein A. FOXI3 is a protein-coding gene in humans, located on chromosome 2p11.2, that encodes the forkhead box I3 transcription factor, which plays a critical role in regulating gene expression during embryonic development of ectodermal and pharyngeal structures, including hair follicles, teeth, the inner ear, and craniofacial features. The FOXI3 protein contains a conserved forkhead DNA-binding domain and a C-terminal transactivation domain, enabling it to function as a sequence-specific transcription factor that activates RNA polymerase II-mediated transcription, with its activity modulated by interactions such as with the Protein Phosphatase 2A (PP2A) complex. It is involved in key developmental processes, such as the induction of the otic placode, specification of preplacodal ectoderm, and epithelial-mesenchymal transition (EMT) in pharyngeal arch derivatives, restricting neural plate border progenitors to placodal and epidermal fates while preventing neural crest formation. Expression of FOXI3 begins broadly in the epiblast during early embryogenesis, becomes restricted to nonneural ectoderm and the preplacodal region (PPR), and is prominent in developing hair placodes, whisker follicles, tooth buds, and the otic placode before subsiding; in adults, it shows limited expression, primarily in placental tissue.
CABT-BL1555 is suitable for use in IHC-P (1:100–1:500), IHC-F (1:100–1:500), IF (immunofluorescence) (1:100–1:500), ICC/IF (1:100–1:500) applications.
CABT-BL1555 is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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