Anti-FOSL2 monoclonal antibody (DMABT-H13767)

Mouse anti-Human FOSL2 monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
3C3
Species Reactivity
Human
Immunogen
FOSL2 (NP_005244, 207 a.a. ~ 296 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
FOSL2; FOS-like antigen 2; fos-related antigen 2; FLJ23306; FRA2; FRA-2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FOSL2 (FOS Like Antigen 2) is a Protein Coding gene. Among its related pathways are Corticotropin-releasing hormone and ERK Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOSL1. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
Antigen Description
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts. Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene. 0The function about FOSL2 antigen include protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity.
Pathway
Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem.

Citations


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References


Gast, H; Muller, A; et al. CD40 activation induces NREM sleep and modulates genes associated with sleep homeostasis. BRAIN BEHAVIOR AND IMMUNITY 27:133-144(2013).
Doucet, JP; Nakabeppu, Y; et al. Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of Delta FosB-like protein(s) in both the rodent and primate striatum. EUROPEAN JOURNAL OF NEUROSCIENCE 8:365-381(1996).

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