FBXL5 blocking peptide (DAG-P0389)

Synthetic FBXL5 blocking peptide for BL Datasheet

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Nature
Synthetic
Tag/Conjugate
Unconjugated
Sequence Similarities
Contains 1 F-box domain.Contains 7 LRR (leucine-rich) repeats.
Cellular Localization
Cytoplasm > perinuclear region.
Alternative Names
The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded.
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
UniProt ID
Antigen Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]
Function
iron ion binding; protein binding; ubiquitin-protein ligase activity;
Synonyms
FBXL5; F-box and leucine-rich repeat protein 5; FBL4; FBL5; FLR1; F-box/LRR-repeat protein 5; F-box protein FBL5; p45SKP2-like protein; F-box protein FBL4/FBL5;

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