Anti-FBXL18 monoclonal antibody (DMABT-H13728)

Mouse anti-Human FBXL18 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
4I6
Species Reactivity
Human
Immunogen
FBXL18 (NP_079239,2a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
FBXL18; F-box and leucine-rich repeat protein 18; F-box/LRR-repeat protein 18; Fbl18; FLJ11467; FLJ10776
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FBXL18 (F-Box And Leucine-Rich Repeat Protein 18) is a Protein Coding gene. The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.
Antigen Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Citations


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References


Muniz, JRC; Guo, KD; et al. Molecular Architecture of the Ankyrin SOCS Box Family of CuI5-Dependent E3 Ubiquitin Ligases. JOURNAL OF MOLECULAR BIOLOGY 425:3166-3177(2013).
Woo, HR; Chung, KM; et al. ORE9, an F-box protein that regulates leaf senescence in Arabidopsis. PLANT CELL 13:1779-1790(2001).

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