Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]
Function
NF-kappaB binding; heat shock protein binding; protein binding; protein domain specific binding; protein kinase binding; protein kinase regulator activity; ubiquitin binding; ubiquitin protein ligase binding
Synonyms
FAF1; Fas (TNFRSF6) associated factor 1; hFAF1; CGI-03; HFAF1s; UBXD12; UBXN3A; FAS-associated factor 1; UBX domain protein 3A; TNFRSF6-associated factor 1; UBX domain-containing protein 12; UBX domain-containing protein 3A
Citations
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