Tag/Conjugate
Unconjugated
Purity
> 95 % by SDS-PAGE.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Reconstitution
EZH1 peptide is supplied as 1mg of dried peptide. When the peptide is reconstituted in 1 mL strile water, the concentration will be 1 mg/mL.
Introduction
EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]
Synonyms
EZH1; enhancer of zeste homolog 1 (Drosophila); KMT6B; histone-lysine N-methyltransferase EZH1; ENX-2;
Citations
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Wang, GG; et al. Selective Inhibition of EZH2 and EZH1 Enzymatic Activity By a Small Molecule Suppresses MLL rearrangement-Induced Leukemia. BLOOD 124:-(2014).
He, AB; Ma, Q; et al. Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart. CIRCULATION RESEARCH 110:406-U102(2012).