Product Overview
Blocking/Immunizing peptide for anti-EXT2 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Function
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; contributes_to acetylglucosaminyltransferase activity; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; glucuronosyltransferase acti
Synonyms
EXT2; exostosin 2; exostoses (multiple) 2; exostosin-2; Glucuronosyl N acetylglucosaminyl proteoglycan 4 alpha N acetylglucosaminyltransferase; N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase; SOTV; multiple exostoses protein 2; putative tumor suppressor protein EXT2; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase; glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase;
Citations
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Clement, A; Wiweger, M; et al. Regulation of Zebrafish Skeletogenesis by ext2/dackel and papst1/pinscher. PLOS GENETICS 4:-(2008).
Murakami, K; Namikawa, K; et al. Nerve injury induces the expression of EXT2, a glycosyltransferase required for heparan sulfate synthesis. NEUROSCIENCE 141:1961-1969(2006).