This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Function
actin binding;
Synonyms
ENC1; ectodermal-neural cortex 1 (with BTB-like domain); NRPB; ectoderm-neural cortex protein 1; ENC 1; kelch like 37 (Drosophila); KLHL37; PIG10; TP53I10; kelch-like 35; kelch-like protein 37; p53-induced gene 10 protein; nuclear matrix protein NRP/B; tumor protein p53 inducible protein 10; nuclear restricted protein, BTB domain-like (brain); CCL28; ENC-1; KLHL35; FLJ39259; FLJ57577;
Citations
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