Human DUSP8 blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-DUSP8/HVH5 antibody

Target

DUSP8 / HVH5

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

Function

MAP kinase tyrosine/serine/threonine phosphatase activity; hydrolase activity; protein tyrosine phosphatase activity;

Synonyms

DUSP8; dual specificity phosphatase 8; C11orf81, chromosome 11 open reading frame 81; dual specificity protein phosphatase 8; FLJ42958; H1 phosphatase; vaccinia virus homolog; HB5; HVH 5; serine/threonine specific protein phosphatase; H1 phosphatase, vaccinia virus homolog; dual specificity protein phosphatase hVH-5; HVH8; HVH-5; C11orf81; FLJ42476;