Synthetic Human DUSP8 blocking peptide for Apuri, BL, ELISA
Blocking/Immunizing peptide for anti-DUSP8/HVH5 antibody
Human, Mouse, Cow, Rat
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Shipped at ambient temperature, store at -20°C.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
MAP kinase tyrosine/serine/threonine phosphatase activity; hydrolase activity; protein tyrosine phosphatase activity;
DUSP8; dual specificity phosphatase 8; C11orf81, chromosome 11 open reading frame 81; dual specificity protein phosphatase 8; FLJ42958; H1 phosphatase; vaccinia virus homolog; HB5; HVH 5; serine/threonine specific protein phosphatase; H1 phosphatase, vaccinia virus homolog; dual specificity protein phosphatase hVH-5; HVH8; HVH-5; C11orf81; FLJ42476;