Ubiquitously expressed at low levels. Expression is highest in skeletal muscle, heart, spleen and placenta.
Contains 1 BED-type zinc finger.
Nucleus. In granular structures.
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This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5 untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]
DNA binding; metal ion binding; protein dimerization activity; transposase activity;
ZBED1; zinc finger, BED-type containing 1; ALTE; DREF; TRAMP; hDREF; zinc finger BED domain-containing protein 1; dREF homolog; Ac-like transposable element; DNA replication-related element binding factor; BED-type zinc finger domain-containing protein 1;