Product Overview
Blocking/Immunizing peptide for anti-DISC1 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Function
protein binding;
Synonyms
DISC1; disrupted in schizophrenia 1; disrupted in schizophrenia 1 protein; SCZD9; C1orf136; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457;
Citations
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Ghoshal, K; Motiwala, T; et al. HOXB13, a Target of DNMT3B, Is Methylated at an Upstream CpG Island, and Functions as a Tumor Suppressor in Primary Colorectal Tumors. PLOS ONE 5:-(2010).
Pedrosa, E; Locker, J; et al. Survey of Schizophrenia and Bipolar Disorder Candidate Genes using Chromatin Immunoprecipitation and Tiled Microarrays (ChIP-chip). JOURNAL OF NEUROGENETICS 23:341-352(2009).
COA
Certificate of Analysis
