General Notes
This product (Catalog No. CABT-BL1269) is a rabbit-derived polyclonal antibody raised against human DHX15, targeting the amino acid region 568–795 of the protein. It has been affinity purified by Protein A. DHX15, officially known as DEAH-box helicase 15, is a human protein-coding gene located on chromosome 4p15.2 that encodes an ATP-dependent RNA helicase essential for pre-mRNA splicing and spliceosome function. This enzyme, also referred to as PRP43 or hPrp43, unwinds RNA structures using ATP hydrolysis and participates in the disassembly of post-splicing spliceosomal complexes, ensuring efficient RNA processing in the nucleus. Ubiquitously expressed across human tissues, with particularly high levels in bone marrow and lymph nodes, DHX15 plays critical roles beyond splicing, including antiviral innate immunity by acting as a coreceptor for RIG-I-like receptor (RLR) signaling to promote interferon production against RNA viruses.
CABT-BL1269 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
CABT-BL1269 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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