Anti-DDX56 monoclonal antibody (DMABT-H12502)

Mouse anti-Human DDX56 monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
5D6
Species Reactivity
Human, Rat
Immunogen
DDX56 (NP_061955, 450 a.a. ~ 547 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
DDX56; DEAD (Asp-Glu-Ala-Asp) box helicase 56; DEAD (Asp Glu Ala Asp) box polypeptide 56; probable ATP-dependent RNA helicase DDX56; NOH61; nucleolar helicase of72kDa
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DDX56 (DEAD-Box Helicase 56) is a Protein Coding gene. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include nucleic acid binding and hydrolase activity. This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity. Probable ATP-dependent RNA helicase DDX56 is an enzyme that in humans is encoded by the DDX56 gene. 0The function about DDX56 antigen include ATP binding; ATP-dependent RNA helicase activity; RNA binding; helicase activity; hydrolase activity; nucleotide binding.

Citations


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References


Yasuda-Inoue, M; Kuroki, M; et al. Distinct DDX DEAD-box RNA helicases cooperate to modulate the HIV-1 Rev function. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 434:803-808(2013).
Xu, ZK; Hobman, TC; et al. The helicase activity of DDX56 is required for its role in assembly of infectious West Nile virus particles. VIROLOGY 433:226-235(2012).

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