General Notes
This product (Catalog No. CABT-BL1218) is a rabbit-derived polyclonal antibody raised against human DDRGK1, targeting the amino acid region 1–314 of the protein. This antibody exhibits cross-reactivity with Human DDRGK1 from mouse and rat. It has been affinity purified by Protein A. DDRGK1, also name as C20orf116, is a member of the DDRGK domain-containing protein family with unknown function. Depletion of DDRGK1 inhibits cell proliferation and invasion. Expression of NF-κB target genes showed the most significant decrease after depleting of DDRGK1, suggesting that DDRGK1 may play an important role in the NF-κB signaling pathway. DDRGK1 interacts with IκBα and regulates its stability, thereby regulates the NF-κB transcriptional activity. DDRGK1 acts as an important regulator of the NF-κB pathway.
CABT-BL1218 is suitable for use in Western blot (WB) (1:2,000–1:10,000), IHC (1:500–1:2,000), IF/ICC (1:50–1:500) applications.
CABT-BL1218 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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