This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.
Synonyms
HCST; hematopoietic cell signal transducer; phosphoinositide 3 kinase adaptor protein , PIK3AP; DAP10; DKFZP586C1522; DNAX activation protein 10; KAP10; kinase assoc pro of ~10kDa; kinase assoc protein; membrane protein DAP10; DNAX-activation protein 10; transmembrane adapter protein KAP10; phosphoinositide-3-kinase adaptor protein; PIK3AP;
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