Synthetic Mouse CDK4 blocking peptide for BL
cdk 4 ( C - term ) peptide ( mouse )
PBS with 100ug BSA 0.1% sodium azide
Keep as concentrated solution, aliquot and store at 4°C.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
ATP binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase activity; kinase activity; nucleotide binding; protein binding; protein complex binding; protein kinase activity; protein serine/threonine kinase activi
CDK4; cyclin-dependent kinase 4; PSK-J3; p34< PSK-J3> /cdk4; serine/threonine kinase; cyclin dependent kinase 4; cell division protein kinase 4; Crk3;