Anti-CREG1 monoclonal antibody (DMABT-H13505)
Mouse anti-Human CREG1 monoclonal antibody for WB, IHC, sELISA, ELISA
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CREG1 (NP_003842,232a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
CREG1; cellular repressor of E1A-stimulated genes 1; cellular repressor of E1A stimulated genes , CREG; protein CREG1; CREG
CREG1 (Cellular Repressor Of E1A Stimulated Genes 1) is a Protein Coding gene. Among its related pathways are Senescence and Autophagy. GO annotations related to this gene include oxidoreductase activity and transcription corepressor activity. An important paralog of this gene is CREG2. The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.
May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R. Protein CREG1 is a protein that in humans is encoded by the CREG1 gene. 0The function about CREG1 antigen include FMN binding; oxidoreductase activity; transcription corepressor activity; transcription factor binding.
Senescence and Autophagy, organism-specific biosystem.
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Peng, F; Han, YL; et al. Overexpression of cellular repressor of E1A-stimulated genes inhibits TNF-alpha-induced apoptosis via NF-kappa B in mesenchymal stem cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 406:601-607(2011).
Peng, CF; Han, YL; et al. Overexpressing Cellular repressor of E1A-stimulated genes promote hypoxia-induced VEGF paracrine via HIF-1 alpha in mesenchymal stem cells. CARDIOLOGY 126:48-48(2013).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.