Human COPS6 peptide

Specificity

Widely expressed.

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Belongs to the peptidase M67A family. CSN6 subfamily.Contains 1 MPN (JAB/Mov34) domain.

Purity

70 - 90% by HPLC.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]

Function

protein binding;

Synonyms

COPS6; COP9 signalosome subunit 6; CSN6; MOV34-34KD; COP9 signalosome complex subunit 6; SGN6; hVIP; H_NH0506M12.12; MOV34 homolog, 34 kD; signalosome subunit 6; vpr-interacting protein; COP9 subunit 6 (MOV34 homolog, 34 kD); JAB1-containing signalosome subunit 6; COP9 constitutive photomorphogenic homolog subunit 6;