CNAP1/hCAP-D2 is a regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condensed chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. It may target the condensin complex to DNA via its C-terminal domain (referenced from Swissprot).
Function
histone binding; histone binding; protein binding;
Synonyms
NCAPD2; non-SMC condensin I complex, subunit D2; CNAP1; CAP-D2; hCAP-D2; condensin complex subunit 1; XCAP-D2 homolog; chromosome-associated protein D2; chromosome condensation related SMC associated protein 1; chromosome condensation-related SMC-associated protein 1;
Citations
Publication ()
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