General Notes
This product (Catalog No. CABT-BL4390) is a rabbit-derived IgG polyclonal antibody raised against human CLDN8, targeting the amino acid region 21–120 of the protein. This antibody exhibits cross-reactivity with CLDN8 from mouse, rat, dog, pig, cow, horse, and rabbit. It has been affinity purified by Protein A. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.
CABT-BL4390 is suitable for use in Western blot (WB) (1:500–1:2,000), ELISA (1:5,000–1:10,000) applications.
CABT-BL4390 is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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