Anti-CITED4 monoclonal antibody (DMABT-H13442)

Mouse anti-Human CITED4 monoclonal antibody for WB, IHC, IF, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
5G7
Species Reactivity
Human
Immunogen
CITED4 (NP_597724.1, 131 a.a. ~ 184 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CITED4; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4; cbp/p300-interacting transactivator 4; transcriptional co activator 4; MRG-2; MSG1-related protein 2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CITED4 (Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 4) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is CITED1. The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors.
Antigen Description
Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. The function about CITED4 antigen include transcription coactivator activity.

Citations


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References


Nangaku, M; Mimura, I; et al. Role of Uremic Toxins in Erythropoiesis-Stimulating Agent Resistance in Chronic Kidney Disease and Dialysis Patients. JOURNAL OF RENAL NUTRITION 25:160-163(2015).
Lau, WM; Doucet, M; et al. CITED2 modulates estrogen receptor transcriptional activity in breast cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 437:261-266(2013).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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