Anti-CITED4 monoclonal antibody (DMABT-H13442)
Mouse anti-Human CITED4 monoclonal antibody for WB, IHC, IF, ELISA
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CITED4 (NP_597724.1, 131 a.a. ~ 184 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
CITED4; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4; cbp/p300-interacting transactivator 4; transcriptional co activator 4; MRG-2; MSG1-related protein 2
CITED4 (Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 4) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is CITED1. The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors.
Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. The function about CITED4 antigen include transcription coactivator activity.
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Lau, WM; Doucet, M; et al. CITED2 modulates estrogen receptor transcriptional activity in breast cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 437:261-266(2013).
Nangaku, M; Mimura, I; et al. Role of Uremic Toxins in Erythropoiesis-Stimulating Agent Resistance in Chronic Kidney Disease and Dialysis Patients. JOURNAL OF RENAL NUTRITION 25:160-163(2015).
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