Anti-CITED1 monoclonal antibody (DMABT-H13441)

Mouse anti-Human CITED1 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
6I7
Species Reactivity
Human
Immunogen
CITED1 (NP_004134, 94 a.a. ~ 193 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CITED1; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1; MSG1; cbp/p300-interacting transactivator 1; melanocyte-specific gene 1; melanocyte-specific protein 1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CITED1 (Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 1) is a Protein Coding gene. Among its related pathways are TGF-beta Receptor Signaling Pathway and Regulation of nuclear SMAD2/3 signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is CITED4. This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described.
Antigen Description
Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. Cbp/p300-interacting transactivator 1 is a protein that in humans is encoded by the CITED1 gene. 0The function about CITED1 antigen include LBD domain binding; chromatin binding; co-SMAD binding; protein C-terminus binding; protein binding; protein homodimerization activity; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription regulatory region DNA binding.
Pathway
Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem.

Citations


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References


Prasad, ML; Pellegata, NS; et al. Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors. MODERN PATHOLOGY 18:48-57(2005).
Prasad, ML; Pellegata, NS; et al. CITED1 protein expression suggests papillary thyroid carcinoma in high throughput tissue microarray-based study. THYROID 14:169-175(2004).

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