Anti-CGGBP1 monoclonal antibody (DMABT-H13427)

Mouse anti-Human CGGBP1 monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
2E22
Species Reactivity
Human
Immunogen
CGGBP1 (NP_003654, 58 a.a. ~ 167 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CGGBP1; CGG triplet repeat binding protein 1; CGG triplet repeat-binding protein 1; CGGBP; p20 CGG binding protein; p20 CGGBP
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CGGBP1 (CGG Triplet Repeat Binding Protein 1) is a Protein Coding gene. Diseases associated with CGGBP1 include fragile x syndrome. GO annotations related to this gene include RNA polymerase II regulatory region sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding. CGGBP1 influences expression of the FMR1 gene (MIM 309550), which is associated with the fragile X mental retardation syndrome (MIM 300624), by specifically interacting with the 5-prime (CGG)n-3-prime repeat in its 5-prime UTR.
Antigen Description
Binds to nonmethylated 5-d(CGG)(n)-3 trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. CGG triplet repeat-binding protein 1 is a protein that in humans is encoded by the CGGBP1 gene. 0The function about CGGBP1 antigen include DNA binding; double-stranded DNA binding.

Citations


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References


Yano, H; Wang, BE; et al. Identification of (CAG)(n) and (CGG)(n) repeat-binding proteins, CAGERs expressed in mature neurons of the mouse brain. EXPERIMENTAL CELL RESEARCH 251:388-400(1999).

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