Anti-CEP250 monoclonal antibody (DMABT-H13459)

Mouse anti-Human CEP250 monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
5D23
Species Reactivity
Human
Immunogen
CNAP1 (AAH28182, 1240 a.a. ~ 1339 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CEP250; centrosomal protein 250kDa; centrosomal protein 2 , CEP2; centrosome-associated protein CEP250; C NAP1; 250 kDa centrosomal protein
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CEP250 (Centrosomal Protein 250) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Organelle biogenesis and maintenance. GO annotations related to this gene include protein kinase binding and protein C-terminus binding. An important paralog of this gene is CROCC2. This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Antigen Description
Probably plays an important role in centrosome cohesion during interphase. Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene. This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Furthermore, CEP135 is also required for the centriolar localization of CEP250. 0The function about CEP250 antigen include protein C-terminus binding; protein binding; protein kinase binding.
Pathway
Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; G2/M Transition, organism-specific biosystem; Loss of Nlp from mitotic centrosomes, organism-specific biosystem; Loss of proteins required for interphase microtubule organization??from the centrosome, organism-specific biosystem; Mitotic G2-G2/M phases, organism-specific biosystem.

Citations


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References


Mack, GJ; Rees, J; et al. Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome. ARTHRITIS AND RHEUMATISM 41:551-558(1998).
Cooper, CDO; Lawrie, CH; et al. Identification and Characterization of Peripheral T-Cell Lymphoma-Associated SEREX Antigens. PLOS ONE 6:-(2011).

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