Anti-CDK3 monoclonal antibody (DMABT-H13385)

Mouse anti-Human CDK3 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
4D23
Species Reactivity
Human
Immunogen
CDK3 (NP_001249, 206 a.a. ~ 305 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CDK3; cyclin-dependent kinase 3; cell division protein kinase 3
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CDK3 (Cyclin-Dependent Kinase 3) is a Protein Coding gene. Among its related pathways are GADD45 Pathway and Cell Cycle Control of Chromosomal Replication. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK4. This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
Antigen Description
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. Cell division protein kinase 3 is an enzyme that in humans is encoded by the CDK3 gene. CDK3 complements cdc28 mutants of Saccharomyces cerevisiae suggesting that it may be involved in cell cycle control. CDK3 can phosphorylate histone H1 and interacts with an unknown type of cyclin. The function about CDK3 antigen include ATP binding; cyclin-dependent protein kinase activity; nucleotide binding.

Citations


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References


Wang, HC; Shao, NS; et al. BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. ONCOGENE 15:143-157(1997).
Zhang, H; Adl, SM; et al. Two distinct classes of mitotic cyclin homologues, Cyc1 and Cyc2, are involved in cell cycle regulation in the ciliate Paramecium tetraurelia. JOURNAL OF EUKARYOTIC MICROBIOLOGY 46:585-596(1999).

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