Anti-CDK20 monoclonal antibody (DMABT-H13204)
Mouse anti-Human CDK20 monoclonal antibody for IHC, ELISA
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CCRK (AAH02655,2a.a. ~ 275 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
CDK20; cyclin-dependent kinase 20; CCRK, cell cycle related kinase; p42; CAK-kinase p42; CDK-activating kinase p42
CDK20 (Cyclin-Dependent Kinase 20) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL3. The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue Thr-160. The function about CDK20 antigen include ATP binding; cyclin-dependent protein kinase activity; nucleotide binding.
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Davis, JJ; Tkac, J; et al. Peptide Aptamers in Label-Free Protein Detection: 2. Chemical Optimization and Detection of Distinct Protein Isoforms. ANALYTICAL CHEMISTRY 81:3314-3320(2009).
Ikezawa, K; Ohtsubo, M; et al. Role of cyclin E and cyclin E-dependent kinase in mitogenic stimulation by cementum-derived growth factor in human fibroblasts. FASEB JOURNAL 12:1233-1239(1998).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.