Mouse anti-Human CDK20 monoclonal antibody for IHC, ELISA
CDK20 (Cyclin-Dependent Kinase 20) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL3. The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue Thr-160. The function about CDK20 antigen include ATP binding; cyclin-dependent protein kinase activity; nucleotide binding.
Korshunov, A; Golanov, A; et al. The prognostic significance of DNA topoisomerase II-alpha (Ki-S1), p21/Cip-1, and p27/Kip-1 protein immunoexpression in oligodendrogliomas - An analysis of 91 cases. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 125:892-898(2001).
Huang, LW; Chao, SL; et al. Down-regulation of p27 is associated with malignant transformation and aggressive phenotype of cervical neoplasms. GYNECOLOGIC ONCOLOGY 85:524-528(2002).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.