Anti-CDK20 monoclonal antibody (DMABT-H13204)

Mouse anti-Human CDK20 monoclonal antibody for IHC, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
5E7
Species Reactivity
Human
Immunogen
CCRK (AAH02655,2a.a. ~ 275 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CDK20; cyclin-dependent kinase 20; CCRK, cell cycle related kinase; p42; CAK-kinase p42; CDK-activating kinase p42
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CDK20 (Cyclin-Dependent Kinase 20) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL3. The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Antigen Description
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue Thr-160. The function about CDK20 antigen include ATP binding; cyclin-dependent protein kinase activity; nucleotide binding.

Citations


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References


Wang, Y; Chen, AD; et al. Mannose-Binding Lectin Inhibits Monocyte Proliferation through Transforming Growth Factor-beta 1 and p38 Signaling Pathways. PLOS ONE 8:-(2013).
Menendez, JA; Vellon, L; et al. Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erb B-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin (TM)) in breast cancer cells with Her-2/neu oncogene amplification. ANNALS OF ONCOLOGY 16:359-371(2005).

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