General Notes
This product (Catalog No. CABT-BL4339) is a rabbit-derived polyclonal antibody raised against human CDIPT. It has been affinity purified by Protein A. CDIPT, also known as CDP-diacylglycerol--inositol 3-phosphatidyltransferase or phosphatidylinositol synthase (PIS), is a protein-coding gene in humans located on chromosome 16p11.2 that encodes an enzyme critical for the de novo biosynthesis of phosphatidylinositol (PI). This enzyme catalyzes the transfer of the phosphatidyl moiety from CDP-diacylglycerol to inositol, forming PI, which serves as a precursor for phosphoinositides involved in essential cellular processes such as membrane structure, signal transduction, and vesicle trafficking. Mutations in CDIPT have been associated with rare disorders, including developmental delays, seizures, and plasma protein metabolism issues, highlighting its role in human health. The gene's expression is ubiquitous, with highest levels in tissues such as the ovary, adipose, liver, and skeletal muscle, underscoring PI's importance in lipid metabolism and signaling pathways.
CABT-BL4339 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
CABT-BL4339 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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