Human CD27 ELISA Matched Antibody Pair (ABPR-0167)

Regulatory status: For research use only, not for use in diagnostic procedures.

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Species Reactivity
Human
Intended Use
This antibody pair set comes with matched antibody pair to detect and quantify protein level of human CD27.
General Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Reconstitution And Storage
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.

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References


Schildknecht, A; Miescher, I; et al. Priming of CD8(+) T cell responses by pathogens typically depends on CD70-mediated interactions with dendritic cells. EUROPEAN JOURNAL OF IMMUNOLOGY 37:716-728(2007).
van Olffen, RW; de Bruin, AM; et al. CD70-Driven Chronic Immune Activation Is Protective against Atherosclerosis. JOURNAL OF INNATE IMMUNITY 2:344-352(2010).

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