Human FAM175A peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

15 amino acids near the amino terminus of human CCDC98.

Purity

> 95 % by SDS-PAGE.

Format

Lyophilized

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Reconstitution

FAM175A peptide is supplied as 1mg of dried peptide. When the peptide is reconstituted in 1 mL strile water, the concentration will be 1 mg/mL.

Introduction

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.

Entrez Gene ID

Synonyms

FAM175A; family with sequence similarity 175, member A; ABRA1; CCDC98; BRCA1-A complex subunit Abraxas; abraxas protein; coiled-coil domain containing 98; coiled-coil domain-containing protein 98;