This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB.
Synonyms
CARD6; caspase recruitment domain family, member 6; caspase recruitment domain-containing protein 6; CINCIN1; caspase recruitment domain protein 6; CARD-containing inhibitor of Nod1 and Cardiak-induced NF-kB activation;
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