Fusion protein corresponding to residues near the C terminal of human calpain 7
Conjugate
Unconjugated
Applications
Application Notes
IHC: 1:50-1:200
General Notes
This product (Catalog No. CABT-BL842) is a rabbit-derived IgG polyclonal antibody raised against human CAPN7. This antibody exhibits cross-reactivity with CAPN7 from mouse. It has been affinity purified by protein A. Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. CABT-BL842 is suitable for use in IHC (1:50–1:200) application. CABT-BL842 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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