This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008]
Function
calcium-dependent protein kinase inhibitor activity; protein kinase binding;
Synonyms
CAMK2N2; calcium/calmodulin-dependent protein kinase II inhibitor 2; CAMKIIN; CAM-KIIN; CaM-KII inhibitory protein;
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