Anti-C1GALT1 monoclonal antibody (DMABT-H13172)

Mouse anti-Human C1GALT1 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
2G2
Species Reactivity
Human
Immunogen
C1GALT1 (NP_064541, 264 a.a. ~ 363 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
C1GALT1; core2synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; C1GALT; core2beta3 Gal T; T synthase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
C1GALT1 (Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-Beta-Galactosyltransferase 1) is a Protein Coding gene. Diseases associated with C1GALT1 include iga glomerulonephritis and hypersensitivity vasculitis. Among its related pathways are Metabolism and O-linked glycosylation. GO annotations related to this gene include transferase activity, transferring glycosyl groups and glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. An important paralog of this gene is C1GALT1C1. The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.
Antigen Description
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development. The function about C1GALT1 antigen include glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; metal ion binding; transferase activity, transferring glycosyl groups.
Pathway
Metabolic pathways, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Mucin type O-Glycan biosynthesis, organism-specific biosystem; Mucin type O-Glycan biosynthesis, conserved biosystem; O-glycan biosynthesis, mucin type core, organism-specific biosystem; O-glycan biosynthesis, mucin type core, conserved biosystem; O-linked glycosylation of mucins, organism-specific biosystem.

Citations


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References


Yang, M; Li, FG; et al. CagA, a major virulence factor of Helicobacter pylori, promotes the production and underglycosylation of IgA1 in DAKIKI cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 444:276-281(2014).
Suzuki, H; Raska, M; et al. Cytokines Alter IgA1 O- Glycosylation by Dysregulating C1GalT1 and ST6GalNAc-II Enzymes*. JOURNAL OF BIOLOGICAL CHEMISTRY 289:5330-5339(2014).

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