CEL peptide

Helical piles have emerged as an attractive foundation system for offshore applications with renewed interest from the offshore community. Significant research gap currently exists in transferring this technology offshore and this paper discusses how existing and emerging knowledge can be successfully used to bridge some of the gaps. We focus on the Coupled Eulerian Lagrangian (CEL) large deformation finite element (LDFE) modelling technique that is commercially available and can be used to model the three-dimensional installation process with consideration of strain rate and softening effects in soft offshore clays. A helical pile of L = 7.5 m long is modelled with one or two large-diameter helices (D = 2 m) attached to a central shaft of d = 0.5 m in diameter.The net effect of strain rate and softening is to increase the installation torque. The measured torque is within the range of 200-400 kN.m for the offshore clay and the pile geometry studied. Additional helices increase the uplift force but to a lesser degree than that of the measured torque. Remoulding induced strength reduction is found to be within the range of 25-33% of the intact clay strength. Issues of extracting and reusing offshore helical pile foundations are discussed.

Biopolymer blends and structural modifications with phenol and hydroxymethylcarbonyl (HMC) are studied to show the ability to interact with amino acids as promising to act as HIV protease inhibitors. Chitosan (Cs), cellulose (Cel), starch (Str) and gelatin (Gel) as well as their blends as Cs/Cel; Cs/Str; Cs/Gel with ratios 3:1; 2:2; 1:3 were subjected to molecular modeling. These biopolymers, as well as their blends, are calculated with quantum mechanical calculations at PM6 level of theory. QSAR, surface area, and volume properties of the interaction of phenol and HMC upon Cs/Cel; Cs/Str; Cs/Gel in the different positions of the four units are calculated at the same level of theory. QSAR descriptors for studied polymers show a change in their physical properties as result of blending. Depending on QSAR calculations, the interaction of phenol and HMC with Cs/Cel and Cs/Str blends for ratio 1:3 through the first unit increases the reactivity of these modified structures. The solubility of modified blends is increased by increasing chitosan units in the proposed modified blends. The surface area of modified Cs/Cel ratios increases comparing with modified Cs/Str and Cs/Gel ratios. This recommends the modified blends of Cs/Cel ratio can be used as promising HIV protease inhibitors drugs.