BCL2A1 blocking peptide (CDBP5186)

Synthetic BCL2A1 blocking peptide for IB Datasheet

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Nature
Synthetic
Immunogen
13 amino acids near the amino terminus of human Bfl-1.
Species Reactivity
Human, mouse, rat
Tag/Conjugate
Unconjugated
Format
Liquid
Concentration
200 μg/mL
Size
0.05mg
Storage
-20°C
UniProt ID
Antigen Description
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function
BH domain binding; protein binding; protein heterodimerization activity; protein homodimerization activity
Synonyms
BCL2A1; BCL2-related protein A1; GRS; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5; bcl-2-related protein A1; bcl2-L-5; protein BFL-1; bcl-2-like protein 5; hematopoietic BCL2-related protein A1; hemopoietic-specific early response protein

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